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KIR and disease: a model system or system of models?
Author(s) -
Khakoo Salim I.,
Carrington Mary
Publication year - 2006
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2006.00459.x
Subject(s) - biology , disease , context (archaeology) , immunology , computational biology , genetics , evolutionary biology , medicine , paleontology , pathology
Summary: The discovery of an unexpected level of diversity among the killer cell immunoglobulin‐like receptors has led to a search for their role in human disease. Due to their polymorphism and also that of their human leukocyte antigen class I ligands, these studies are difficult to perform and complex to interpret. Nevertheless, as the number of data sets increase, consistent trends and themes are beginning to emerge in both viral and inflammatory disorders. In this review, we summarize the findings from a number of disease association studies and discuss these in the context of the activating and inhibitory roles of the members of this gene family.