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Licensing of natural killer cells by self‐major histocompatibility complex class I
Author(s) -
Yokoyama Wayne M.,
Kim Sungjin
Publication year - 2006
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.2006.00458.x
Subject(s) - major histocompatibility complex , biology , immunology , histocompatibility , class (philosophy) , self tolerance , human leukocyte antigen , genetics , immune system , antigen , t cell , epistemology , philosophy
Summary: Natural killer (NK) cells have potent capacities to immediately kill cellular targets and produce cytokines that may potentially damage normal self‐tissues unless they are kept in check. Such tolerance mechanisms are incompletely understood. Here we discuss recent studies suggesting that NK cells undergo a host major histocompatibility complex (MHC) class I‐dependent functional maturation process, termed ‘licensing’. Ironically, licensing directly involves inhibitory receptors that recognize target cell MHC class I molecules and block activation of NK cells in effector responses. This process results in two types of tolerant NK cells: functionally competent (licensed) NK cells, whose effector responses are inhibited by self‐MHC class I molecules through the same receptors that conferred licensing, and functionally incompetent (unlicensed) NK cells.