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Major histocompatibility complex class II polymorphisms in primates
Author(s) -
Bontrop Rondd E.,
Otting Nel,
Groot Natasja G.,
Doxiadis Gaby G. M.
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01403.x
Subject(s) - major histocompatibility complex , biology , primate , haplotype , evolutionary biology , allele , genetics , mhc class i , nonhuman primate , immune system , gene , ecology
Summary: In the past decade, the major histocompatibility complex (MHC) class II region of several primate species has been investigated extensively. Here we will discuss the similarities and differences found in the MHC class II repertoires of primate species including humans, chimpanzees, rhesus macaques, cotton‐top tamarins and common marmosets. Such types of comparisons shed light on the evolutionary stability of MHC class II alleles, lineages and loci as well as on the evolutionary origin and biological significance of haplotype configurations.