Premium
Conservation and diversification of MHC class I and its related molecules in vertebrates
Author(s) -
Hashimoto Keiichiro,
Okamura Kazuhiko,
Yamaguchi Hisateru,
Ototake Mitsuru,
Nakanishi Teruyuki,
Kurosaiva Yoshikazu
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01384.x
Subject(s) - biology , diversification (marketing strategy) , major histocompatibility complex , evolutionary biology , mhc class ii , immunology , genetics , computational biology , immune system , marketing , business
Summary: The elucidation of the complete peptide‐binding domains of the highly polymorphic shark MHC class I genes offered us an opportunity to examine the characteristics of their predicted protein products in the light of the latest advance m the structural studies of the MHC class I molecules. The results suggest that the fundamental characteristics in the T‐cell recognition of the MHC class I molecule/peptide complex are expected to have been established at the early stage of the vertebrate evolution. The elucidation of the typical classical class I molecules from fishes and also of some MHC class I‐related molecules may help us Co explore the common denominator of the ancient class I molecules.