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Intracellular traffic to compartments for MHC class II peptide loading: signals for endosomal and polarized sorting
Author(s) -
Bakke Oddmund,
Nordeng Tommy W.
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01365.x
Subject(s) - endosome , microbiology and biotechnology , mhc class i , biology , antigen presentation , cd74 , mhc class ii , antigen , major histocompatibility complex , antigen processing , cross presentation , intracellular , mhc restriction , immune system , immunology , t cell
Summary: In this review we focus on the traffic of MHC class II and endocytosed antigens to intracellular compartments where antigenic pep‐tides are loaded. We also discuss briefly the nature of the peptide loading compartment and the sorting signals known to direct antigen receptors and MHC class II and associated molecules to this location, MHC dass II molecules are expressed on a variety of polarized epithelial and endothelial cells, and polarized cells are thus potentially important for antigen presentation. Here we review some cell biological aspects of polarized sorting of MHC class II and the associated invariant chain and the signals that are involved in the sorting process to the basolateral domain. The molecules involved in sorting and loading of peptide may modulate antigen presentation, and in particular we discuss how invariant chain may change the cellular phenotype and the kinetics of the endosomal pathway.