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Generating MHC class I ligands from viral gene products
Author(s) -
Yewdell Jonathan,
Anton Luis C.,
Bacik Igor,
Schubert Ulrich,
Snyder Heidi Link,
Bennink Jack R.
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01359.x
Subject(s) - endoplasmic reticulum , proteases , mhc class i , biology , proteasome , major histocompatibility complex , cd8 , antigen processing , microbiology and biotechnology , antigen presentation , peptide , cytosol , antigen , gene , virology , biochemistry , t cell , immune system , genetics , enzyme
Summary: MHC class I molecules function to present peptides comprised of eight to I 1 residues to CD8+ T lymphocytes. Here we review the efforts of our laboratory lo understand bow cells generate such peptides from viral gene products. We particularly focus on the nature of substrates acted on by cytosolic proteases, the contribution of proteasomes and nun‐proteasomal proteases lo peptide generation, the involvement of ubiquitination in peptide generation, the intracellular localization of proteasome generation of antigenic peptides, and the trimming of peptides in the endoplasmic reticulum.