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Vaccines and passive immunological approaches for the control of fertility and hormone‐dependent cancers
Author(s) -
Talwar C. P.
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01348.x
Subject(s) - human chorionic gonadotropin , ovulation , antibody , luteinizing hormone , hormone , medicine , active immunization , immunology , pregnancy , immunization , immunogenicity , active immunotherapy , immunotherapy , endocrinology , biology , immune system , genetics
Summary: Reviewed here is the development of a vaccine against the human chorionic gonadotropin that prevents pregnancy in sexually active women without impairment of ovulation or derangement of menstrual regularity. Also reviewed are the vaccines inducing antibodies against the luteinizing hormone‐releasing hormone, which have immunotherapeutic potential in prostatic hypertrophy and other sex hormone‐dependent male and female cancers. The adoption of pasive immunization using humanized recombinant antihormone antibodies is advocated for assured efficacy and safe, prompt therapeutic action.