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Genetic models of abnormal apoptosis in lymphocytes
Author(s) -
Refaeli Yosef,
Parijs Luk,
Abbas Abul K.
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01322.x
Subject(s) - apoptosis , biology , programmed cell death , mechanism (biology) , immune system , immunology , lymphocyte , animal model , neuroscience , genetics , endocrinology , philosophy , epistemology
Summary: Apoptosis is a critical mechanism for regulating cell numbers during development, normal responses to hormones and other stimuli, and immune and inflammatory reactions. Recent advances in defining the biochemical mechanisms of cell death, and the development of animal models with isolated defects in cell death pathways, have led to an increasing appreciation of the pathophysiologic importance of lymphocyte apoptosis. In this article, we review our current understanding of the pathways and roles of apoptosis in lymphocytes, with an emphasis on trans‐genic and knockout models. We also summarize the relevance of these animal models to human diseases.