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Dissecting the role of CD4 + T cells in autoimmune diabetes through the use of TCR transgenic mice
Author(s) -
Suri Anish,
Katz Jondthdn D.
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01306.x
Subject(s) - major histocompatibility complex , immunology , autoimmune disease , t cell receptor , autoimmunity , islet , genetically modified mouse , biology , immune system , pathogenesis , effector , transgene , diabetes mellitus , disease , beta cell , immunopathology , mechanism (biology) , t cell , genetics , medicine , endocrinology , gene , antibody , philosophy , epistemology
Summary: Insulin‐dependent diabetes mellitus (IDDM) is an Immunological disorder wherein autoimmune‐mediated destruction of islet cells in che pancreas results in persistent hyperglycemia. The non‐obese diabetic mouse model of IDDM has revealed che importance of multiple factors that impact upon che disease process; however, understanding of primary immune mechanisms leading to IDDM remains elusive. The emergence of transgenic mouse models for IDDM has made importance contributions towards clarifying many of these factors, including the cell types, che various effector molecules and the genetic elements Involved in the pathogenesis of IDDM, In this review, we will focus on the primary mechanism and mediators of islet β‐cell death, the impact of T‐helper lymphocytes on disease progression and the potential role of major histocompatibility complex class II molecules in conferring susceptibility to IDDM.