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CD 30 prevents T‐cell responses to non‐lymphoid tissues
Author(s) -
Heath William R.,
Kurts Christian,
Caminschi Irina,
Carbone Francis R.,
Miller Jacques F. A. P.
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01303.x
Subject(s) - biology , antigen , lymphatic system , lymph , immunology , t cell , peripheral tolerance , antigen presentation , cross presentation , parenchyma , adoptive cell transfer , microbiology and biotechnology , pathology , immune tolerance , immune system , medicine , botany
Summary: Self antigens can induce T‐cell tolerance via a mechanism termed cross‐tolerance. This involves the transfer of peripheral tissue antigens to professional APC for presentation in the draining lymph nodes. In this site, CD8 + T cells are activated, proliferate, and are slowly deleted by a CD95‐dependent mechanism. Prior to their deletion, some activated cells leave the lymph nodes and encounter antigens on peripheral parenchymal tissues. Without functional CD30, these cells proliferate extensively and cause substantial tissue damage. Thus, CD30 limits autoreactivity, acting as a ‘brake’ on T‐cell proliferation after recognition of autoantigens on parenchymal tissues.