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Walking through the forest of transgenic models of human disease
Author(s) -
Ey Elizabeth E.,
Flavell Richard A.,
Frost Robert
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01301.x
Subject(s) - human disease , transgene , genetically modified mouse , disease , context (archaeology) , computational biology , biology , animal model , neuroscience , bioinformatics , medicine , genetics , pathology , gene , paleontology , endocrinology
Summary: In the investigation of human disease, molecular biology has provided Immunologists with several enormously powerful tools. Trans‐genic and knockout mice provide animal models to investigate mechanisms, as well as aid in the design of therapies for these diseases. These mice have been useful in several different ways. First, as direct models of disease they provide direct tools for the study of the disease. Second, expression of individual molecules can be altered in the context of established disease models. We describe here some of the models in use as well as the limitations and promise of this research.