Premium
General and specific immunosuppression caused by antiviral T‐cell responses
Author(s) -
Zinkernagel Rolf M.,
Planz Oliver,
Ehl Stephan,
Battegay Manuel,
Odermatt Bernhard,
Klenerman Paul,
Hengartner Hans
Publication year - 1999
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1999.tb01300.x
Subject(s) - biology , immunosuppression , immune system , virology , cytotoxic t cell , immunology , lymphocytic choriomeningitis , antigen , virus , antibody , cd8 , t cell , biochemistry , in vitro
Summary: Immunosuppression caused by the non‐cytopathic lymphocytic choriomeningltis virus (LCMV) (an RNA virus) is mediated by anti‐viral cytotoxic T cells that destroy LCMV‐infected cells, also of the immune system. While this immunopathological destruction of antigen‐presenting cells, macrophages and follicular dendritic cells and of some CD4 + T cells causes general immunosuppression and impairs immune response to third party antigens, it also enhances exhaustion/deletion of LCMV‐specific CD8 + T‐cell responses. LCMV seems in addition to infect neutralizing antibody‐producing B cells via the specific receptor; immunopathological LCMV‐specific CD8T T‐cell‐mediated elimination of these infected B cells (but not of uninfected internal virus antigen‐specific B cells) causes a highly specific immunosuppression that delays neutralizing antibody responses and thereby enhances virus persistence. Both generalized and specific immunosuppression by CD8 + T‐cell‐mediated immunopathology may be involved in human infections with HIV; hepatitis B virus or hepatitis C virus.