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Recombination‐based mechanisms for somatic hypermutation
Author(s) -
Kong Qingzhong,
Harris Reuben S.,
Maizels Nancy
Publication year - 1998
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1998.tb01430.x
Subject(s) - somatic hypermutation , biology , genetics , mutation , saccharomyces cerevisiae , recombination , flp frt recombination , gene conversion , somatic cell , germline mutation , mutation rate , gene , genetic recombination , antibody , b cell
Summary: We review some experiments designed to test recombination‐based mechanisms for somatic hypermutation in twice, particularly mechanisms involving templated mutation or gene conversion. As recombination and repair functions are highly conserved among prokaryotes and eukaryotes, pathways of mutation in microorganisms may prove relevant to the mechanism of somatic hypermutation. Estherichia coli initates a recombination‐based pathway of mutation in response to environmental stimuli, and this “adaptive” pathway of mutation has striking similarities with somatic hypermutation, as does a process of mutagenic repair that occurs at double‐strand breaks in Saccharomyces cerevisiae. We present model for recombination‐based hypermutation of the immunoglobulin loci which could result in cither templated cir non‐templated mutation.