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Progress in understanding the mechanism and consequences of somatic hypermutation
Author(s) -
Storb Ursula
Publication year - 1998
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1998.tb01424.x
Subject(s) - somatic hypermutation , biology , mechanism (biology) , somatic cell , genetics , evolutionary biology , gene , antibody , epistemology , b cell , philosophy
This volume is dedicated lo the somatic hypermutation of immunoglobulin (Ig) genes. There has been considerable progress in the past few years in our understanding of the molecular mechanism of this process, the cellular events, and the diseases in which somatic hypermutation seems to play a major role. Most of the major issues are discussed in the chapters of this book or alluded to in this Introduction, and future challenges are outlined. Many mysteries remain on all the issues.