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CK‐1, a putative chemokine of rainbow trout (Oncorhynchus mykiss)
Author(s) -
Dixon Brian,
Shum Benny,
Adams Erin J.,
Magor Katharine,
Hedrick Ronald P.,
Muir David G.,
Parham Peter
Publication year - 1998
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1998.tb01274.x
Subject(s) - rainbow trout , biology , chemokine , trout , immunology , zoology , genetics , fishery , fish <actinopterygii> , immune system
Summary: Chemokines arc small inducible proteins that direct the migration of leukocytes. While chemokines are well characterised in mammals, they have yet to be identified in fish. We have isolated a cDNA clone from rainbow trout (Oncorhynchus mykiss) which encodes a protein (CK‐1) having structural features typical of chemokines. Amino‐acid residues that define the β‐chemokines of mammals are conserved in CK‐1, including the paired cysteine motif, CC. Further similarities are shared with the C6 subfamily of β‐chemokines. In contrast, the organisation of the CK‐f gene is closer to that of mammalian α‐chemokine genes than β‐chemokine genes. The CK‐1 gene is present in all four salmonid species examined and the nucleotide sequences of the exons are highly conserved. CK‐1 has characteristics in common with mammalian α and β‐chemokine suggesting that this salmonid chemokine gene preserves traits once present in the ancestral chemokine gene from which modern mammalian chemokine genes evolved.