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The Syk family of protein tyrosine kinases in T‐cell activation and development
Author(s) -
Chu David H.,
Morita Craig T,
Weiss Arthur
Publication year - 1998
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1998.tb01238.x
Subject(s) - syk , signal transduction , kinase , biology , microbiology and biotechnology , tyrosine kinase , receptor tyrosine kinase , proto oncogene tyrosine protein kinase src , receptor , tyrosine , protein tyrosine kinases , biochemistry
Summary: The processes of T‐cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signaling molecules are shared between [he receptor signaling pathways, including two families of cytoplasmic protein tyrosine kinases, the Src family and the Syk family. The two Syk family members expressed in T cells, Syk and ZAP‐70, are structurally similar but are expressed at different times during rhymic development and during T‐cell activation. These two kinases, althongh they share many physical features, differ in terms of biochemical activity and regulation. We discuss the overlapping and distinct characteristics of Syk and ZAP‐70 in T‐cell signaling and the potential biological importance of their differences.