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T‐cell fate
Author(s) -
Hedrick Stephen M.,
Sharp Leslie L.,
Hedrick Stephen M.,
Sharp Leslie
Publication year - 1998
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1998.tb01233.x
Subject(s) - cell lineage , biology , lineage (genetic) , cell fate determination , cd8 , developmental biology , evolutionary biology , cellular differentiation , perspective (graphical) , t cell , immunology , genetics , immune system , transcription factor , gene , computer science , artificial intelligence
Summary: Recent studies suggest that lineage commitment steps, which occur during T‐cell differentiation, follow principles in common with fate specification in simple invertebrates. Here we review T‐cell development from the perspective of developmental biology. We present models for αβγσ Y5 and CD4 vs CD8 lineage commitment that are consistent with previously published and newly presented experiments.