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Natural killer and T cells of innate and adaptive immunity: lymphoid compartments with different requirements for common γ chain‐dependent cytokines
Author(s) -
Santo James P.,
Colucci Francesco,
GuyGrand Delphine
Publication year - 1998
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1998.tb01227.x
Subject(s) - innate lymphoid cell , biology , acquired immune system , immunology , common gamma chain , cytokine , immunity , innate immune system , immune system , receptor , cytokine receptor , interleukin 10 , microbiology and biotechnology , genetics
Summary: A group of cytokines, including interleukin‐2, ‐4, 7, ‐9 and ‐15, are related through the usage of a shared receptor subunit, the common cytokine receptor γ chain, γ c γ c ‐dependent cytokines critically affect the development and maintenance of the lymphoid system. This review will highlight our current knowledge on the γ c ‐dependent cytokine network and on the non‐redundant roles that these cytokines play in the development and homeostasis of T and natural killer cells involved in innate and adaptive immunity.