Premium
The modular architecture of leukocyte cell‐surface receptors
Author(s) -
Cambell Ioin D.
Publication year - 1998
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1998.tb01184.x
Subject(s) - receptor , modular design , biology , immune receptor , cell surface receptor , computational biology , microbiology and biotechnology , sequence (biology) , immune system , immunology , computer science , genetics , operating system
Summary: Cells of the immune system have a large number of protein receptors on their surfaces, with a wide range of binding functions. They are, however, constructed from a limited set of protein structural units, which are recognisable at the sequence level. The 3D structure of many of these domains, or modules, is now known. These modular units and their structures are reviewed here. The ways in which they are assembled into multidomain receptor chains and oligomeric complexes of receptors are also discussed.