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The cytokine stew and innate resistance to L. monocytogenes
Author(s) -
Mocci Simonetta,
Dalrymple Stacie A.,
Nishinakamura Ryuichi,
Murray Richard
Publication year - 1997
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1997.tb00996.x
Subject(s) - biology , innate immune system , immunology , listeria monocytogenes , immune system , immunity , cytokine , acquired immune system , tumor necrosis factor alpha , genetics , bacteria
Summary:The Listeria monocytogenes (L. monocytogenes) infection model has been a useful system to evaluate the cellular interactions leading to host immunity. The initiation of the innate immune response in naive animals and subsequent progression to acquired immunity represent an integrated system with numerous layers of complexity. Coincident with experimental infection is the induction of cytokines. Cytokines, which are soluble mediators of cell growth, maintenance and function, form a network of pleiotropic stimuli that serve as one of the main driving forces for the progressive development of cellular responses. A variety of in vivo approaches, such as injection of the recombinant cytokines themselves or antibodies lo neutralize their activity, have been used to define these stimuli. Perhaps one of the most useful tools is that of germline‐manipulated animals. One of the many cytokines implicated in resistance to L. monocytogenes Infection is interleukin (IL)‐6, a molecule associated with diverse infectious and pathophysiological disease states. This review concentrates on various cytokines (IL‐1, TNFα, IFN‐γ. IL‐12, IL‐10 and the colony‐stimulating factors (CSF)) thought to play a role during the innate host response to L. monocytogenes infection, with a special emphasis on studies using IL‐6‐deficient mice. Additionally, we show unpublished data obtained when the concepts learned from L. monocytogenes infection in IL‐6‐deficieni mice were applied :o other infection models.