Immunological reconstitution following bone marrow transplantation | Zendy

Parkman Robertson | Zendy; Weinberg Kenneth I. | Zendy

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Immunological reconstitution following bone marrow transplantation

Author(s) -

Parkman Robertson,

Weinberg Kenneth I.

Publication year - 1997

Publication title -

immunological reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.839

H-Index - 223

eISSN - 1600-065X

pISSN - 0105-2896

DOI - 10.1111/j.1600-065x.1997.tb00975.x

Subject(s) - immunology , biology , transplantation , immunity , bone marrow transplantation , antigen , bone marrow , immunodeficiency , haematopoiesis , severe combined immunodeficiency , hematopoietic stem cell transplantation , stem cell , antibody , immune system , medicine , genetics , gene

Summary: The recipients of hematopoietic stem cell transplants are characterized by an immunodeficiency of varying severity and duration. Their immunoincompetence is due in part to: 1) a lack of sustained transfer of donor immunity, 2) a recapitulation of lymphoid ontogeny, 3) the effects of graft‐versus‐host disease and its therapy, and 4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen‐specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens.

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