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Immunological reconstitution following bone marrow transplantation
Author(s) -
Parkman Robertson,
Weinberg Kenneth I.
Publication year - 1997
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1997.tb00975.x
Subject(s) - immunology , biology , transplantation , immunity , bone marrow transplantation , antigen , bone marrow , immunodeficiency , haematopoiesis , severe combined immunodeficiency , hematopoietic stem cell transplantation , stem cell , antibody , immune system , medicine , genetics , gene
Summary: The recipients of hematopoietic stem cell transplants are characterized by an immunodeficiency of varying severity and duration. Their immunoincompetence is due in part to: 1) a lack of sustained transfer of donor immunity, 2) a recapitulation of lymphoid ontogeny, 3) the effects of graft‐versus‐host disease and its therapy, and 4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen‐specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens.