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From stem cells to lymphocytes; biology and transplantation
Author(s) -
Aguila Hector L.,
Akashi Koichr,
Domen Jos,
Gondy Kimberly L.,
Lagasse Eric,
Wright Douglas E.,
Wassman Irving L.,
Morrison Scan J.,
Mebius Reina E.,
Shizuu Judy,
Strober Samuel,
Uchida Nohuko
Publication year - 1997
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1997.tb00971.x
Subject(s) - homing (biology) , biology , stem cell , haematopoiesis , immunology , transplantation , cxcr4 , major histocompatibility complex , histocompatibility , microbiology and biotechnology , immune system , antigen , human leukocyte antigen , medicine , ecology , chemokine
Summary: We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cell This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T‐cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl‐2 in regulating homeostasis in the hematopoietic system is discussed.