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Arousal and inhibition of human NK cells
Author(s) -
Lanier Lewis L.,
Corliss Brian,
Phillips Joseph H.
Publication year - 1997
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1997.tb00947.x
Subject(s) - receptor , biology , cytotoxicity , microbiology and biotechnology , mhc class i , inhibitory postsynaptic potential , major histocompatibility complex , cell , immunology , immune system , neuroscience , in vitro , genetics
Summary: NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell‐mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors.