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Allorecognition by murine natural killer cells: lysis of T‐lymphoblasts and rejection of bone‐marrow grafts
Author(s) -
George Thaddeus,
Lawrence Yu Yik Yeung,
Liu Jingxuan,
Davenport Colleen,
Lemieux Suzanne,
Stoneman Earl,
Mathew Porunelloor A.,
Kumar Vinay,
Bennett Michael
Publication year - 1997
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1997.tb00937.x
Subject(s) - biology , lymphoblast , immunology , bone marrow , major histocompatibility complex , mhc class i , lymphokine activated killer cell , interleukin 21 , natural killer cell , allorecognition , interleukin 12 , antigen , microbiology and biotechnology , in vitro , immune system , cytotoxic t cell , t cell , cell culture , genetics
Summary: Natural killer (NK) cells of inbred mice reject allogeneic bone‐marrow cells, and NK cells of F1 hybrid mice can reject parental bone‐marrow cells (hybrid resistance). In some cases these patterns of rejection can be mimicked in vitro by utilizing IL‐2 cultured NK effector cells and allogeneic or parental T‐lymphoblasts as target cells. Lysis of allogeneic parental targets in vitro can be explained on the basis of the missing self hypothesis. Subsets of NK cells that bear non‐overlapping MHC class I inhibitory receptors belonging to the Ly49 family lyse allogeneic targets because they do not express self class I molectiles of the NK cell donor. Parental strain targets are lysed because they do not express all of the self class I antigens of the Fl hybrid, and hence fail to deliver inhibitory signals to all subsets of Fl NK cells. The expression of Ly49 receptors on NK cells is regulated by liost MHC to ensure maximal sensitivity to alterations in self class I molecules and to prevent autoreactivity. In many instances, however, the rejection of allogeneic bone marrow cells in vivo cannot be readily explained by the missing self hypothesis. In these instances, it appears that rejection is initiated by class 1 MHC receptors on NK ceils Out recognize allogeneic class I molecules as non‐self, and activate rather than inhibit NK cell function.