Premium
Distinctive Developmental Origins and Specificities of Murine CD5 + B Cells
Author(s) -
Hardy Richard R.,
Carmack Condie E.,
LI YUE Sheng,
Hayakawa Kyoko
Publication year - 1994
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1994.tb00660.x
Subject(s) - cd5 , biology , germline , b cell , spleen , population , fetus , immunology , somatic cell , microbiology and biotechnology , antibody , genetics , medicine , gene , pregnancy , environmental health
SUMMARY CD5 + B cells constitute a small fraction of cells in the spleen of adult mice that exhibit numerous features serving to distinguish them from the bulk of IgD ++ CD5 − “conventional” B cells. In this review we focus on two major questions relating to this population: 1) the relationship of CD5 + B cells to other B cells; and 2) the distinctive enrichment of particular autoreactive specificities in this subset. The nature of their origins is clarified by a thorough analysis of intermediate stages of early B‐cell development in both fetal and adult tissues. The reactivity to bromeliad‐treated mouse red blood cells serves as a prototype system for the investigation of biased specificities in CD5 + B cells. These lines of investigation lead us to propose that CD5 + B cells in the adult are the remnant of a distinct fetal B‐cell differentiation pathway wherein selection of cells from this fetal/neonatal population into the adult long‐lived pool results in the over‐expression of certain germline‐encoded autoreactivities.