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T‐Cell Receptor β‐Chain Binding to Enterotoxin Superantigens
Author(s) -
Irwin Michael J.,
Hudson Keith R.,
Ames Kristina T.,
Fraser John D.,
Gascoigne Nicholas R. J.
Publication year - 1993
Publication title -
immunological reviews
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1993.tb01530.x
Subject(s) - superantigen , enterotoxin , immune system , biology , immunology , t cell receptor , receptor , antigen , t cell , microbiology and biotechnology , genetics , gene , escherichia coli
The last few years have seen an enormous jump in our knowledge and understanding of T-cell activation by superantigens. Clearly, a great number of infectious and parasitic organisms utilize superantigens as part of a strategy to evade the immune response of their host. The ability to modulate superantigen effects will give us new means to fight infections, and the knowledge of T-cell activation that we have gained from study of superantigens will, in turn, allow us to modulate the immune system in new ways.