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Clonal Deletion of Autospecific B Lymphocytes
Author(s) -
Nemazee David,
Russell David,
Arnold Bernd,
Hahmmerling Guenter,
Allison Janetfe,
Miller J. F. A. P.,
Morahan Grant,
Buerki Kurt
Publication year - 1991
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1991.tb00600.x
Subject(s) - biology , clonal deletion , immunology , genetics , immune system , t cell , t cell receptor
Using mice transgenic for functional, rearranged immunoglobulin heavy and light chain genes, it can be demonstrated that B lymphocytes reactive with cell surface-bound class I MHC antigen can be controlled by clonal elimination. Even low-affinity cell-bound ligands can induce deletion. Deletion can occur in the pre-B to B cell transitional stage or after the B cells exist the bone marrow, depending on where the cells first encounter autoantigen. IgD appears to play no role in protecting cells from deletion. It is argued that defects in B-cell tolerance alone may be sufficient to lead to systemic autoimmunity.