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Structure, Sequence and Polymorphism in the HLA‐D Region
Author(s) -
Trowsdale John,
Young John A. T.,
Kelly Adrian R.,
Austin Penelope J.,
Carson Susan,
Meunter Helene,
So Alex,
Erlich Henry A.,
Spielman Richard S.,
Bodmer Julia,
Bodmer Walter F.
Publication year - 1985
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1985.tb01129.x
Subject(s) - genetics , biology , gene , gene duplication , polymorphism (computer science) , sequence (biology) , human leukocyte antigen , sequence analysis , beta (programming language) , allele , antigen , computer science , programming language
Molecular analysis of the HLA-D region has uncovered a complex array of related genes encompassing a minimum of 6 alpha and 7 beta chain sequences. A high level of polymorphism is characteristic of the DQ alpha and beta genes, as well as DR beta. The DP genes, both alpha and beta, are also polymorphic, though to a lesser extent. The genes fit into the previously established loci: DP, DQ and DR, except for a newly-discovered sequence, DZ alpha, which is approximately equally related to all of the other alpha chain genes. Analysis of the polymorphism and evolution of the HLA-D region, by examination of the sequences, calls for several independent duplication events in the generation of this family of genes.