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The Human T Cell Receptor: Analysis with Cytotoxic T Cell Clones
Author(s) -
Reinherz Ellis L.,
Meuer Stefan C.,
Schlossman Stuart F.
Publication year - 1983
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1983.tb01085.x
Subject(s) - library science , cancer , sociology , biology , computer science , genetics
Employing human T lymphocyte clones and monoclonal antibodies to their surface glycoproteins, the antigen receptors on these cells have been defined. Based on functional and biochemical data, it is shown that each T cell displays two major recognition units on its surface. One structure consists of the antigen-binding region (Tin-T3) which views antigen X in the context of a polymorphic region of an MHC molecule. A second (T8 or T4) serves as an associative recognition structure for a constant region of the class I or class II molecule. The antigen-binding structure is a heterodimer of disulfide linked 49KD and 43KD subunits, which contains clonally unique variable regions. These are non-covalently associated with the 20/25KD monomorphic T3 molecule expressed on all mature human T lymphocytes. The associative-recognition element on an individual clone is either T8 or T4, depending on its subset derivation. It is likely that these glycoproteins bind to constant regions of class I or class II molecules, respectively, and are independent of the Tin-T3 complex complex.