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Responsiveness to HY Antigen Ir Gene Complementation and Target Cell Specificity
Author(s) -
Simpson Elizabeth,
Gordon Robert D.
Publication year - 1977
Publication title -
immunological reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.839
H-Index - 223
eISSN - 1600-065X
pISSN - 0105-2896
DOI - 10.1111/j.1600-065x.1977.tb00235.x
Subject(s) - complementation , cytotoxic t cell , haplotype , biology , gene , antigen , recombinant dna , genetics , microbiology and biotechnology , t cell , cell , immunology , phenotype , allele , immune system , in vitro
The H-2 restricted nature of the cytotoxic T cell responses to the HY antigen in mice has been reviewed, together with mapping data for the H-2 K and/or D association of responses to male cells of the following haplotypes: H-2b, H-2d, H-2k, H-2s. Ir gene complementation is implicated in the HY response of a number of F1 mice derived from non-responder parental haplotypes, and in one recombinant strain. Thus, at least two and possibly more Ir genes are involved in the anti-HY response, in addition to the K and/or D gene products with which HY is obligatorily associated, certainly at the target cell level.