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Involvement of the ubiquitin‐proteasome system in the stabilization of cell–cell contacts in human keratinocytes
Author(s) -
Löffek Stefanie,
BrucknerTuderman Leena,
Magin Thomas M.
Publication year - 2012
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2012.01564.x
Subject(s) - desmosome , microbiology and biotechnology , proteasome , desmoplakin , ubiquitin , intracellular , cell , aggresome , biology , chemistry , gene , genetics
Desmosomes are highly organized intercellular junctions composed of a number of interacting proteins that provide mechanical integrity to epithelial tissues. Mutations in genes encoding desmosomal proteins, including desmoplakin ( DP ), are associated with human hereditary diseases affecting skin integrity. The detailed mechanism of desmosome assembly remains, despite many efforts, incompletely understood. Recently, the ubiquitin‐proteasome system ( UPS ) has been suggested to be an important regulatory system for the proper intracellular trafficking of proteins. Here, we provide evidence for a calcium‐independent, but UPS ‐dependent, stabilization of cell–cell contacts in human keratinocytes, which might be mediated by the maintenance of DP at desmosomes.