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Advantages of histamine H 4 receptor antagonist usage with H 1 receptor antagonist for the treatment of murine allergic contact dermatitis
Author(s) -
Matsushita Ayuko,
Seike Masahiro,
Okawa Haruka,
Kadawaki Yayoi,
Ohtsu Hiroshi
Publication year - 2012
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2012.01559.x
Subject(s) - antagonist , pharmacology , histamine , interleukin 1 receptor antagonist , medicine , receptor antagonist , contact dermatitis , allergic contact dermatitis , histamine h1 receptor , atopic dermatitis , immunology , allergy , receptor
Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well‐known corticosteroid treatments, H 1 receptor ( H 1 R ) antagonists also have been used. This study observed effects of histamine H 4 receptor ( H 4 R ) antagonist usage with H 1 R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6‐trinitro‐1‐chlorobenzene ( TNCB ). The H 1 R antagonist olopatadine hydrochloride and/or the H 4 R antagonist JNJ 7777120 was then administered. Combination therapy was more effective than H 1 R antagonist monotherapy. Serum I g E and levels of interleukin ( IL )‐4, IL ‐5 and IL ‐6 ( T h2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H 1 R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.