Primary cutaneous anaplastic large cell lymphoma shows a distinct mi RNA expression profile and reveals differences from tumor‐stage mycosis fungoides

The mi RNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C‐ ALCL ) patients were analysed with mi RNA microarrays using the same control group of 12 benign inflammatory dermatoses ( BID ) as previously used to study the mi RNA expression profile of tumor‐stage mycosis fungoides ( MF ). We identified 13 differentially expressed mi RNA s between C ‐ ALCL and BID . The up‐regulation of mi R ‐155, mi R ‐27b, mi R ‐30c and mi R ‐29b in C ‐ ALCL was validated by mi RNA ‐ Q ‐ PCR on independent study groups. Additionally, the mi RNA expression profiles of C ‐ ALCL were compared with those of tumor‐stage MF . Although mi RNA microarray analysis did not identify statistically significant differentially expressed mi RNA s, mi RNA ‐ Q ‐ PCR demonstrated statistically significantly differential expression of mi R ‐155, mi R ‐27b, mi R ‐93, mi R ‐29b and mi R ‐92a between tumor‐stage MF and C ‐ ALCL . This study, the first describing the mi RNA expression profile of C ‐ ALCL , reveals differences with tumor‐stage MF , suggesting a different contribution to the pathogenesis of these lymphomas.