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M yo/ N og cells in normal, wounded and tumor‐bearing skin
Author(s) -
Gerhart Jacquelyn,
Hayes Candace,
Scheinfeld Victoria,
Chernick Michael,
GeorgeWeinstein Mindy,
Gilmour Susan
Publication year - 2012
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2012.01503.x
Subject(s) - noggin , chemistry , epidermis (zoology) , microbiology and biotechnology , cell , biology , anatomy , biochemistry , bone morphogenetic protein , gene
Murine and human skin were examined for the presence of M yo/ N og cells that were originally discovered in the chick embryo by their expression of M yo D m RNA , noggin and the G 8 antigen. M yo/ N og cells are the primary source of noggin in telogen hair follicles. They are scarce within the interfollicular dermis and absent in the epidermis. Within 24 h following epidermal abrasion, M yo/ N og cells increase in number in the follicles and appear in the wound. M yo/ N og cells are also recruited to the stroma of tumors formed from v‐Ras‐transformed keratinocytes ( K er/ R as). Human squamous cell carcinomas and malignant melanomas contain significantly more M yo/ N og cells than basal cell carcinomas. M yo/ N og cells are distinct from macrophages, granulocytes and cells expressing alpha smooth muscle actin in the tumor stroma. M yo/ N og cells may be modulators of skin homoeostasis and wound healing, and potential diagnostic and therapeutic targets in skin cancer.