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Lesional Th17 cells and regulatory T cells in bullous pemphigoid
Author(s) -
Arakawa Masataka,
Dainichi Teruki,
Ishii Norito,
Hamada Takahiro,
Karashima Tadashi,
Nakama Takekuni,
Yasumoto Shinichiro,
Tsuruta Daisuke,
Hashimoto Takashi
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2011.01378.x
Subject(s) - bullous pemphigoid , pemphigus vulgaris , foxp3 , pemphigoid , pemphigus , pemphigus foliaceus , pathogenesis , interleukin 17 , medicine , immunology , autoimmune disease , inflammation , disease , pathology , immune system , antibody , autoantibody
Th17 cells play crucial roles in the pathogenesis of autoimmune diseases. We previously reported that Th17 cells are recruited to the lesional skin in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The aim of this study was to evaluate lesional Th17 cells and Treg cells in bullous pemphigoid (BP). Correlations between these cells and disease severity of BP were also evaluated. Immunohistochemical studies showed that both IL‐17+ and Foxp3+ cells were present in higher numbers in BP lesions, compared with control skin. IL‐17/CD4 ratio in BP was significantly higher than that in PF. Foxp3/CD4 ratio in BP was significantly less than that in either PV or PF. There were no obvious correlations between these cells and disease severity of BP. This study suggests that, compared with pemphigus, BP shows more Th17 cell‐related inflammation and less Treg‐related regulation.