Premium
Patients with palmoplantar pustulosis have increased IL‐17 and IL‐22 levels both in the lesion and serum
Author(s) -
Murakami Masamoto,
Hagforsen Eva,
Morhenn Vera,
IshidaYamamoto Akemi,
Iizuka Hajime
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2011.01325.x
Subject(s) - palmoplantar pustulosis , pathogenesis , infiltration (hvac) , cytokine , medicine , lesion , interleukin 17 , immunology , psoriasis , interleukin 23 , pathology , physics , thermodynamics
Recent findings about the pathogenesis of pustulosis palmaris et plantaris (PPP), also known as palmoplantar pustulosis, suggest that IL‐17 expression in the acrosyringium as well as infiltration of IL‐17 positive cells, e.g. Langerhans cells may play important roles. However, to date, it has not been established whether circulating IL‐17 related cytokines are involved in PPP. We studied the circulating IL‐17 related cytokines as well as the mRNA levels in lesional skin. IL‐17 related cytokine mRNAs were increased in the PPP lesions compared with the control tissues (five patients vs five controls). The serum levels of TNF‐alpha, IL‐17, IL‐22 and IFN‐gamma also were significantly increased in PPP, but not IL‐23 and IL‐8 (48 patients vs 20 controls). Our findings document that not only the serum IL‐17 but also tissue IL‐17 are elevated in PPP and may be in the pathogenesis of this disorder.