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Study on the roles of β‐catenin in hydrogen peroxide‐induced senescence in human skin fibroblasts
Author(s) -
Tian Liming,
Xie Hongfu,
Xiao Xiao,
Yang Ting,
Hu Yaohua,
Wang Weizhen,
Liu Leishan,
Chen Xiang,
Li Ji
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2011.01324.x
Subject(s) - hydrogen peroxide , senescence , human skin , skin aging , fibroblast , chemistry , microbiology and biotechnology , catenin , biochemistry , medicine , dermatology , biology , signal transduction , genetics , wnt signaling pathway , in vitro
Oxidative stress is one of the most important causes of the cellular senescence process. Previous studies showed that β‐catenin can regulate FoxO3a and this association was enhanced in cells exposed to oxidative stress. It has also been reported that β‐catenin can regulate some senescence‐related proteins. We propose that β‐catenin may play a crucial role in senescence of normal human primary skin fibroblasts (NHSFs). Here, we explored the roles and mechanisms of β‐catenin on H 2 O 2 ‐induced senescence in NHSFs. β‐catenin expression was decreased in NHSFs after H 2 O 2 treatment. Overexpression of β‐catenin in NHSFs led to a marked delay of many senescent phenotypes induced by H 2 O 2 . Furthermore, overexpression of β‐catenin in NHSFs can antagonise the alteration of reactive oxygen species accumulation and some senescence‐related proteins expression induced by H 2 O 2 treatment. Our data demonstrated that β‐catenin can protect NHSFs from H 2 O 2 ‐induced premature senescence by alleviating oxidative stress and regulating some senescence‐related molecules.