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5,7‐Dimethoxyflavone induces melanogenesis in B16F10 melanoma cells through cAMP‐dependent signalling
Author(s) -
Kang YoungGyu,
Choi EunJung,
Choi Yuri,
Hwang JaeKwan
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01236.x
Subject(s) - melanin , hypopigmentation , microphthalmia associated transcription factor , protein kinase b , photoprotection , skin cancer , protein kinase a , chemistry , creb , transcription factor , melanoma , microbiology and biotechnology , gsk 3 , signal transduction , kinase , biology , cancer research , biochemistry , genetics , cancer , gene , photosynthesis
Melanin protects the skin against ultraviolet radiation (UVR) and diverse free radicals. Agents that increase melanin synthesis in melanocytes may reduce UVR‐induced skin damage and skin cancer. In the present study, we evaluated the effects of 5,7‐dimethoxyflavone (5,7‐DMF) on melanogenic protein expression and signalling pathways. We found that 5,7‐DMF significantly increased melanin content by upregulating microphthalmia‐associated transcription factor and related melanogenic proteins. Additionally, 5,7‐DMF increased cAMP levels, which activates a cascade of reactions, such as cAMP responsive element‐binding protein and Akt/glycogen synthase kinase‐3β (GSK‐3β) signalling. Thus, 5,7‐DMF may be an effective pigmentation stimulator for photoprotection and hypopigmentation disorders.