Premium
Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigen
Author(s) -
Ruutu Merja P.,
Chen Xianfeng,
Joshi Ojas,
Kendall Mark A.,
Frazer Ian H.
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01234.x
Subject(s) - stimulus (psychology) , immunogenicity , immune system , antigen , immunology , langerhans cell , population , medicine , psychology , environmental health , psychotherapist
Skin is subjected regularly to mechanical stimulus. Surprisingly, when studying the use of microneedle arrays to introduce antigen into skin, we observed that mechanical stimulus to skin achieved by application of the arrays or a flat metal plate resulted in temporary depletion of Langerhans cells, with the degree of depletion related to the applied stress, whereas no depletion was seen in the interspersed dendritic epidermal T cell population. Further, a significantly impaired immune response to intracutaneous antigen administration was observed in skin recently subjected to mechanical stimulus. This observation may have implications for selection of sites of skin immunisation and for immunogenicity of infections at skin sites routinely subjected to mechanical stimuli.