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Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients
Author(s) -
Torii Kan,
Saito Chiyo,
Furuhashi Takuya,
Nishioka Akiko,
Shintani Yoichi,
Kawashima Kana,
Kato Hiroshi,
Morita Akimichi
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01224.x
Subject(s) - psoriasis , medicine , peripheral blood mononuclear cell , interleukin 17 , immunology , cd3 , tobacco smoke , t cell , immune system , cd8 , in vitro , environmental health , biology , biochemistry
Environmental factors contribute to the increased prevalence of autoimmune diseases via T helper type‐17 cell (Th17) activation. Tobacco smoking increases the risk of psoriasis, but the mechanisms are not clear. We evaluated the percentage of circulating Th17 among CD3 + cells in peripheral blood mononuclear cells (PBMC) obtained from 27 healthy volunteers (2.58 ± 0.80%), 33 smoker (3.55 ± 1.33%) and 21 non‐smoker (3.10 ± 1.14%) patients with psoriasis to elucidate the relation between smoking and psoriasis. More smokers (19/33) than non‐smokers (6/21) had high Th17 levels (Th17/CD3 > 3.38%, mean + 1 SD of healthy volunteers). Tobacco smoke extract (TSE, 7 μl/ml) induced Th17 generation from central memory T cells in vitro . TSE increased interleukin 17 and 22 expression. These findings demonstrate the relation between tobacco smoke and IL‐17 and IL‐22, which exacerbate psoriasis.