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Changes in murine hair with dietary selenium excess or deficiency
Author(s) -
Hwang Seon Wook,
Lee Hyun Jae,
Suh Kee Suck,
Kim Sang Tae,
Park Sung Wook,
Hur Dae Young,
Lee Deborah,
Seo Jong Keun,
Sung Ho Suk
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01207.x
Subject(s) - hair follicle , hair cycle , apoptosis , hair growth , selenium , selenium deficiency , hair loss , atrophy , endocrinology , medicine , cabello , biopsy , biology , chemistry , dermatology , physiology , scalp , oxidative stress , biochemistry , superoxide dismutase , organic chemistry , glutathione peroxidase
It is known that an excess or deficiency of selenium (Se) causes abnormalities in hair. We evaluated changes in the hair follicles associated with Se imbalance in a C57BL/6 mouse model to better understand the role of Se in hair growth. Fifteen C57BL/6 mice were assigned to diets providing excessive, adequate, or deficient amounts of Se. Alopecia with poliosis was observed in the groups receiving either excessive or deficient selenium. Skin biopsy from alopecia patches showed increased telogen hair follicles with epidermal atrophy. There was a significant decrease of anti‐apoptotic Bcl‐2 and an increase of pro‐apoptotic Bax in the excessive‐Se group compared with the adequate group. We suggest that alopecia with poliosis is caused by changes in the hair follicle cycle due to the imbalance of Se and partially influenced by the decrease of the ratio of Bcl‐2/Bax, which is associated with induction of apoptosis of keratinocytes.