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Effects of α‐melanocyte‐stimulating hormone on calcium concentration in SZ95 sebocytes
Author(s) -
Whang Sung Won,
Lee Sang Eun,
Kim Ji Min,
Kim Hyun Jung,
Jeong Se Kyoo,
Zouboulis Christos C.,
Seo Jeong Taek,
Lee Seung Hun
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01199.x
Subject(s) - calcium , endocrinology , medicine , melanocyte , microbiology and biotechnology , phosphorylation , chemistry , melanocyte stimulating hormone , biology , hormone , cancer research , melanoma
Melanocortins have been implicated in human sebum secretion for a long time. However, the signalling pathways of α‐melanocyte‐stimulating hormone (α‐MSH) in human sebocytes expressing melanocortin receptors (MC‐Rs) are still poorly understood. Because calcium ions play a central role in MC‐R signalling, we investigated whether α‐MSH affects calcium signalling in the immortalized human sebocyte cell line SZ95. In addition, we investigated the impact of α‐MSH on MC‐1R expression and lipid synthesis in these cells. α‐MSH increased intracellular calcium levels. α‐MSH‐mediated calcium mobilization originated from intracellular calcium stores and was mediated by inositol triphosphate. Moreover, α‐MSH increased MC‐1R immunoreactivity and lipid synthesis in SZ95 sebocytes in the presence of testosterone. Our data demonstrate that α‐MSH in human sebocytes controls a key cellular signalling pathway, the calcium ion response, which may coordinate MC‐1R‐mediated sebum secretion.