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The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms
Author(s) -
Pinczewski Joel,
Slominski Andrzej
Publication year - 2010
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01169.x
Subject(s) - melanoma , limiting , vitamin d and neurology , medicine , cancer , cancer research , dermatology , mechanical engineering , engineering
Abstract: Hormonally active vitamin D 3 , 1,25‐(OH) 2 D 3 , is believed to have a role in the prevention of cancer formation and in limiting the aggressiveness of cancers that do arise. Therefore, much interest is presently being focused on 1,25‐(OH) 2 D 3 and its analogues as potential treatments for various cancers including melanoma. This article discusses the evidence in favour of a role for 1,25‐(OH) 2 D 3 in protection against the progression of melanocytic lesions and also summarizes the mechanisms by which 1,25‐(OH) 2 D 3 may act to protect against melanoma development and progression.