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I‐Ascorbic acid 2‐phosphate represses the dihydrotestosterone‐induced dickkopf‐1 expression in human balding dermal papilla cells
Author(s) -
Kwack Mi Hee,
Kim Moon Kyu,
Kim Jung Chul,
Sung Young Kwan
Publication year - 2010
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01143.x
Subject(s) - dihydrotestosterone , paracrine signalling , ascorbic acid , dermal papillae , autocrine signalling , chemistry , androgen , medicine , endocrinology , androgen receptor , biology , biochemistry , receptor , hair follicle , food science , prostate cancer , cancer , hormone
Recent studies suggested that dihydrotestosterone (DHT)‐driven alteration in the autocrine and paracrine factors may be a key to androgen‐potentiated balding. Also, we recently claimed that DHT‐inducible dickkopf‐1 (DKK‐1) is one of the key factors involved in the androgen‐potentiated balding. Here, we investigated whether I‐ascorbic acid 2‐phosphate (Asc 2‐P), a derivative of I‐ascorbic acid, could attenuate DHT‐induced DKK‐1 expression in dermal papilla cells (DPCs) from balding scalp. We observed that DHT‐induced DKK‐1 mRNA expression was attenuated in the presence of Asc 2‐P as examined by RT‐PCR analysis. In addition, we found that DHT‐induced activation of luciferase reporter activity was significantly repressed when Asc 2‐P was added together with DHT. Moreover, Asc 2‐P repressed DHT‐induced DKK‐1 protein expression as examined by enzyme‐linked immunosorbent assay (ELISA). Although there will be many hurdles to apply our finding to actual remedies, these results suggest that it would be worthy to evaluate Asc 2‐P or its derivatives for the treatment and prevention of androgen‐driven balding.