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Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene
Author(s) -
Cobb Joanna E.,
Zaloumis Sophie G.,
Scurrah Katrina J.,
Harrap Stephen B.,
Ellis Justine A.
Publication year - 2010
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01132.x
Subject(s) - androgen receptor , single nucleotide polymorphism , biology , gene , haplotype , male pattern baldness , genetics , androgen , genetic association , locus (genetics) , allele , endocrinology , genotype , prostate cancer , cancer , scalp , anatomy , hormone
Please cite this paper as: Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene. Experimental Dermatology 2010; 19 : 1026–1028. Abstract: The gene encoding the androgen receptor ( AR ) is associated with male pattern baldness (androgenetic alopecia – AGA). In case–control and family analyses, we mapped AR and the adjacent intergenic regions. We found evidence for association with two independent loci, one upstream and previously described and the other downstream and apparently novel. The haplotype comprising these SNPs was strongly associated with AGA ( P = 3.75 × 10 −5 ) in 1195 men. We also replicated association with a recently reported non‐coding region on chromosome 20 and found that its association with AGA was less strong and independent of that of AR . Our results will help focus future efforts to further define AGA genetic risk.