Premium
Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT
Author(s) -
Amann Philipp M.,
Schadendorf Dirk,
Owen Robert W.,
Korn Bernhard,
Eichmüller Stefan B.,
Bazhin Alexandr V.
Publication year - 2011
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01127.x
Subject(s) - hacat , retinoic acid , retinoic acid inducible orphan g protein coupled receptor , nuclear receptor , retinoid x receptor gamma , biology , retinoid , microbiology and biotechnology , retinoic acid receptor , retinol , retinal , keratinocyte , receptor , retinoid x receptor alpha , gene expression , cell culture , vitamin , biochemistry , genetics , gene , transcription factor
Please cite this paper as: Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Experimental Dermatology 2010. Abstract: Vitamin A is a pivotal regulator of differentiation and growth of developing and adult skin. Retinoic acid is the major physiologically active form of vitamin A regulating the expression of different genes through retinoic acid nuclear receptors. Here, we present evidence that other vitamin A derivates – retinol and retinal – are also capable of functioning as regulators of gene expression in the keratinocyte cell line HaCaT. We have shown that all‐ trans retinol (ATRol) and all‐ trans retinal (ATRal) are capable of modulating gene expression in keratinocytes, which is not because of vitamin A metabolism in the cells, and retinol and retinal modulate gene expression through nuclear receptors: retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Based on the data, we propose that ATRol and all‐trans retinal, in addition to all‐trans retinoic acid, can function as important regulators of gene expression manifesting their effect through the nuclear receptors RARs and RXRs.