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The expression of microRNA‐203 during human skin morphogenesis
Author(s) -
Wei Tianling,
Orfanidis Kyriakos,
Xu Ning,
Janson Peter,
Ståhle Mona,
Pivarcsi Andor,
Sonkoly Enikö
Publication year - 2010
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01118.x
Subject(s) - involucrin , morphogenesis , filaggrin , epidermis (zoology) , microrna , biology , human skin , loricrin , microbiology and biotechnology , keratinocyte , immunology , genetics , gene , anatomy , atopic dermatitis , cell culture
Please cite this paper as: The expression of microRNA‐203 during human skin morphogenesis. Experimental Dermatology 2010; 19 : 854–856. Abstract: MicroRNAs are small, non‐coding RNAs that regulate gene expression post‐transcriptionally and play important roles in various biological processes. We previously identified miR‐203 as a skin‐ and keratinocyte‐specific microRNA. Moreover, miR‐203 has been implicated in repressing ‘stemness’ in epidermal progenitors. Here, we investigate the expression of miR‐203 and two of its targets, p63 and suppressor of cytokine signalling‐3, during human skin morphogenesis. MiR‐203 in situ hybridization was performed on sections of human foetal skin ranging from 14 to 22 weeks’ gestation and adult skin. MiR‐203 was barely detectable at 14 weeks. Its expression became prominent from week 17 and was most pronounced in the suprabasal layers of the epidermis, while p63 and SOCS‐3 were preferentially expressed in the basal layer. Differentiation markers such as involucrin and filaggrin were expressed mainly in the suprabasal layers of epidermis, similar to miR‐203. Our results support the involvement of miR‐203 in skin morphogenesis.