Premium
Cutaneous T‐cell lymphoma cells are sensitive to rapamycin
Author(s) -
Kremer Melanie,
Sliva Katja,
Klemke ClausDetlev,
Schnierle Barbara S.
Publication year - 2010
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01102.x
Subject(s) - pi3k/akt/mtor pathway , cutaneous t cell lymphoma , cancer research , t cell , lymphoma , cell growth , sirolimus , cell culture , in vivo , medicine , immunology , mycosis fungoides , biology , microbiology and biotechnology , signal transduction , immune system , genetics
Please cite this paper as: Cutaneous T‐cell lymphoma cells are sensitive to rapamycin. Experimental Dermatology 2010; 19 : 800–805. Abstract: Cutaneous T‐cell lymphomas (CTCL) are characterised by clonal expansion of helper T lymphocytes that infiltrate the skin. Only a small number of cell lines exist to study cellular pathways leading to T‐cell transformation and to identify new targets for intervention. We wanted to investigate the inhibition of mTOR as a possible therapeutic target in CTCL. Primary cells of patients with Sézary syndrome (SS) and conventional CTCL cell lines were analysed. Constitutive activation of mTOR was found, and concomitantly, we could show that rapamycin, a specific inhibitor of mTOR, inhibits CTCL cell growth in vitro by induction of cell cycle arrest. Using a previously established animal model for CTCL, we additionally observed upon rapamycin treatment tumor growth inhibition in vivo . In summary, primary cells from patients with SS as well as CTCL cell lines allowed us to identify mTOR as an important target for intervention.