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Prostaglandin D 2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin production
Author(s) -
Masoodi Mojgan,
Nicolaou Anna,
Gledhill Karl,
Rhodes Lesley E.,
Tobin Desmond J.,
Thody Anthony J.
Publication year - 2010
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2010.01098.x
Subject(s) - melanocyte stimulating hormone , melanin , melanoma , melanocyte , endocrinology , hormone , medicine , melanin concentrating hormone , prostaglandin e2 , prostaglandin d2 , prostaglandin , prostaglandin e , immune system , cell culture , biology , microphthalmia associated transcription factor , microbiology and biotechnology , chemistry , cancer research , immunology , enzyme , biochemistry , receptor , tyrosinase , neuropeptide , genetics
Please cite this paper as: Prostaglandin D 2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin production. Experimental Dermatology 2010; 19 : 751–753. Abstract: This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX‐1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. α‐Melanocyte‐stimulating hormone, which had no effect on melanin production in FM55 cells, stimulated PGD 2 production in these cells without affecting PGE 2 . While cAMP pathways may be involved in regulating PGD 2 production, our results suggest that α‐MSH acts independently of cAMP, possibly by regulating the activity of lipocalin‐type PGD synthase. This α‐MSH‐mediated effect may be associated with its role as an immune modulator.