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The role of ultraviolet radiation in melanomagenesis
Author(s) -
Von Thaler AnnaKatharina,
Kamenisch York,
Berneburg Mark
Publication year - 2010
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/j.1600-0625.2009.01025.x
Subject(s) - melanoma , cancer research , ultraviolet radiation , in vivo , in vitro , apoptosis , cell cycle checkpoint , pathogenesis , ultraviolet , medicine , cell cycle , chemistry , dermatology , microbiology and biotechnology , biology , pathology , materials science , genetics , biochemistry , optoelectronics , radiochemistry
Please cite this paper as: The role of ultraviolet radiation in melanomagenesis. Experimental Dermatology 2010; 19: 81–88. Abstract: The role of ultraviolet radiation (UV) in the pathogenesis has been discussed controversially for many decades. Studies in mice (SCID, HGF/SF, SV40T) which develop malignant melanoma, show a role of UVB in melanomagenesis. In contrast to this, the role of UVA is less clear. We will review the recent in vitro and in vivo data in support of the hypothesis that UVA is also involved in the development of malignant melanoma. The role of UVA in p53 activation, apoptosis, cell cycle arrest and photoproduct formation is discussed.